Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 6/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24618063 | 0.82 | PARP15 (0.53) | PARP15PARP10PARP2TDP1FNTA | |
| SCHEMBL20969685 | 0.79 | PARP15 (0.50) | PARP15PARP10PARP2TDP1FNTA | |
| SCHEMBL29024848 | 0.76 | PARP15 (0.64) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL2563096 | 0.76 | PARP10 (0.62) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL16838743 | 0.76 | TDP1 (0.69) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL25727749 | 0.76 | PARP15 (0.57) | PARP15PARP10PARP2 | |
| SCHEMBL18374444 | 0.76 | PARP15 (0.57) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL21051418 | 0.76 | PARP10 (0.62) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL3572304 | 0.76 | PARP15 (0.57) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL20969564 | 0.75 | PARP15 (0.51) | PARP15PARP10PARP2GRM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820860-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | Lieber Institute, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |