Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355278 | 0.85 | SCN10A (0.64) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23327687 | 0.83 | SCN10A (0.67) | SCN10ASCN2ASMN1; SMN2BRD4BRD9 | |
| SCHEMBL23327934 | 0.78 | SCN10A (0.74) | SCN10ASCN2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2939291 | 0.78 | SCN2A (0.54) | SCN10ASCN2ASMN1; SMN2BRD4BRD9 | |
| SCHEMBL5281170 | 0.76 | SCN2A (0.53) | SCN10ASCN2ASMN1; SMN2BRD4BRD9 | |
| SCHEMBL23327945 | 0.76 | SCN10A (0.58) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14108028 | 0.75 | SCN2A (0.60) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23327959 | 0.74 | SCN10A (0.56) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23328014 | 0.74 | SCN10A (0.56) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4638791 | 0.73 | SCN2A (0.53) | SCN10ASCN2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820860-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | Lieber Institute, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |