Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.81 |
| ▸ | JAK3 | P52333 | 20/20 | 0.81 |
| ▸ | JAK2 | O60674 | 12/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | TYK2 | P29597 | 1/20 | 0.68 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL524755 | 0.94 | JAK1 (0.72) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL29357381 | 0.94 | JAK1 (0.72) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL525515 | 0.93 | JAK1 (0.68) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL23356192 | 0.92 | JAK1 (0.81) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29610386 | 0.90 | JAK1 (1.00) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL340566 | 0.90 | JAK1 (1.00) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL23356152 | 0.89 | JAK1 (0.71) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL524594 | 0.87 | JAK1 (0.85) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389088 | 0.87 | JAK1 (0.85) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL525346 | 0.87 | JAK1 (0.74) | JAK1JAK3JAK2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598500-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2021-05-19 | — | — | EP | claimed |