Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.56 |
| ▸ | IKZF2 | Q9UKS7 | 10/20 | 0.51 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.50 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944282 | 1.00 | CRBN (0.56) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL23357926 | 0.95 | CRBN (0.62) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL29944315 | 0.95 | CRBN (0.62) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL29944515 | 0.93 | IKZF2 (0.55) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL23358078 | 0.93 | IKZF2 (0.55) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL23358016 | 0.92 | CRBN (0.53) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL29944312 | 0.91 | IKZF2 (0.52) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL23357932 | 0.91 | IKZF2 (0.52) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL23357985 | 0.91 | CRBN (0.50) | CRBNIKZF2GSPT1DDB1IKZF3 | |
| SCHEMBL29944388 | 0.91 | CRBN (0.50) | CRBNIKZF2GSPT1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061812-B1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL MYERS SQUIBB CO (US) | 2026-03-25 | — | — | EP | claimed |
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-10 | — | — | US | claimed |
| CN-114728950-A | Compounds useful as inhibitors of HELIOS proteins | 百时美施贵宝公司 | 2022-07-08 | — | — | CN | claimed |
| WO-2021101919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-05-27 | — | — | WO | claimed |
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY | 2021-05-20 | — | — | US | claimed |
| EP-4061812-B1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL MYERS SQUIBB CO (US) | 2026-03-25 | — | — | EP | disclosed |
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-10 | — | — | US | disclosed |
| CN-114728950-A | Compounds useful as inhibitors of HELIOS proteins | 百时美施贵宝公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021101919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-05-27 | — | — | WO | disclosed |
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | IKZF2, RPL6, HNRNPR | CRBN 116/4885IKZF2 1/4885GSPT1 2028/4885 |
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | IKZF2, RPL6, HNRNPR | CRBN 116/4885IKZF2 1/4885GSPT1 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.