Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.51 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.51 |
| ▸ | KDM5C | P41229 | 2/20 | 0.49 |
| ▸ | KDM4B | O94953 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9473584 | 0.87 | KDM4C (0.54) | KDM4CSMYD2KDM5CKDM5BFFAR1 | |
| SCHEMBL21310984 | 0.86 | KDM4C (0.68) | KDM4CSMYD2KDM5CKDM4BKDM5B | |
| SCHEMBL30775344 | 0.86 | KDM4C (0.68) | KDM4CSMYD2KDM5CKDM4BKDM5B | |
| SCHEMBL29932993 | 0.83 | KDM1A (0.55) | KDM4CKDM5CKDM4BKDM5BPARP1 | |
| SCHEMBL29933114 | 0.83 | KDM1A (0.53) | KDM4CKDM5CKDM4BKDM5BPARP1 | |
| SCHEMBL28490524 | 0.82 | KDM4C (0.61) | KDM4CSMYD2KDM5CKDM5BFFAR1 | |
| SCHEMBL29163838 | 0.81 | SMYD2 (0.47) | KDM4CSMYD2KDM5CKDM5BFFAR1 | |
| SCHEMBL1758494 | 0.81 | KDM4C (0.51) | KDM4CKDM5CKDM4BKDM5BPARP1 | |
| SCHEMBL29933213 | 0.81 | HDAC1 (0.58) | KDM4CKDM5CKDM4BKDM5BJAK2 | |
| Nitrous Acid SCHEMBL29163839 | 0.81 | KDM4C (0.62) | KDM4CSMYD2KDM5CKDM4BKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356094-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2356094-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |