Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313451 | 0.85 | PTPN1 (0.44) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL1584718 | 0.80 | NOTUM (0.48) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL2060107 | 0.78 | PTPN1 (0.45) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL29377172 | 0.78 | PTPN1 (0.45) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL2317094 | 0.77 | PTPN1 (0.42) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL19798736 | 0.75 | ERN1 (0.43) | PTPN1PDE4BALDH1A1NPC1RAB9A | |
| SCHEMBL4020110 | 0.74 | NPC1 (0.51) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL17215129 | 0.73 | PDE4B (0.44) | PTPN1PDE4BALDH1A1KMT2AMEN1 | |
| SCHEMBL25621200 | 0.72 | HPGD (0.47) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL2505507 | 0.72 | PDE4B (0.39) | PTPN1PDE4BALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358656-A2 | SPIROCYCLIC GPR40 MODULATORS | Amgen, Inc (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-2260017-A1 | CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | Amgen, Inc (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2010045258-A2 | SPIROCYCLIC GPR40 MODULATORS | AMGEN INC. (US) | 2010-04-22 | — | — | WO | disclosed |
| WO-2009111056-A1 | CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | AMGEN INC. (US) | 2009-09-11 | — | — | WO | disclosed |