Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.52 |
| ▸ | GSPT1 | P15170 | 12/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337722 | 0.93 | CRBN (0.54) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL2334587 | 0.92 | CRBN (0.53) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL70103 | 0.89 | CRBN (0.57) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL69198 | 0.89 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL2342025 | 0.88 | CRBN (0.54) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL70502 | 0.84 | CRBN (0.59) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL70504 | 0.84 | CRBN (0.57) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL69518 | 0.83 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL69197 | 0.82 | CRBN (0.61) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL70102 | 0.81 | CRBN (0.56) | CRBNGSPT1DDB1IKZF3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358697-A1 | Isoindoline compounds for use in the treatment of cancer | CELGENE CORPORATION (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010053732-A1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |