Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337919 | 1.00 | AKR1C3 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL7783022 | 0.91 | PTGER4 (0.55) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2336941 | 0.91 | PTGER4 (0.55) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2336935 | 0.91 | PTGER4 (0.55) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2334495 | 0.91 | PTGER4 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2340914 | 0.91 | PTGER4 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2340918 | 0.91 | PTGER4 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL2334504 | 0.91 | PTGER4 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL12300021 | 0.91 | AKR1C3 (0.48) | AKR1C3AKR1C2PTGER4PTGER2AKR1C4 | |
| SCHEMBL7776748 | 0.89 | HDAC8 (0.62) | ABCB1HDAC8PTPN1TNFRSF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236503-B1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2014-02-26 | — | — | EP | disclosed |
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | AKR1C3 1216/4885AKR1C2 764/4885PTGER4 4636/4885 |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | AKR1C3 1216/4885AKR1C2 764/4885PTGER4 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.