Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.41 |
| ▸ | NEK2 | P51955 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339060 | 0.95 | SYK (0.53) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2339783 | 0.95 | SYK (0.53) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2349493 | 0.88 | SYK (0.55) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2276501 | 0.88 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2346422 | 0.86 | PDE4B (0.51) | SYKCYP2C9MAP3K11PDE4BFYN | |
| SCHEMBL2339118 | 0.84 | SYK (0.51) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2273835 | 0.82 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275553 | 0.82 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2343891 | 0.80 | SYK (0.52) | SYKCYP2C9MAP3K11NEK2PDE4B | |
| SCHEMBL2346884 | 0.80 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |