Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342536 | 0.88 | GCK (0.73) | GCKALDH1A1GAAMAPTHPGD | |
| SCHEMBL13439330 | 0.86 | GCK (1.00) | GCKALDH1A1GAAMAPTHPGD | |
| SCHEMBL2342162 | 0.85 | GCK (1.00) | GCKALDH1A1GAAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL2342166 | 0.85 | GCK (0.98) | GCKALDH1A1GAAMAPTHPGD | |
| SCHEMBL2334151 | 0.85 | GCK (1.00) | GCKGRM5 | |
| Hydrochloric Acid SCHEMBL2339960 | 0.84 | GCK (0.98) | GCKALDH1A1GAAMAPTHPGD | |
| SCHEMBL2669231 | 0.83 | GCK (0.82) | GCKALDH1A1GAAMAPTHPGD | |
| SCHEMBL2360810 | 0.82 | GCK (0.66) | GCKALDH1A1GAAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL2336812 | 0.82 | GCK (0.81) | GCKGAAMAPTMEN1NPC1 | |
| SCHEMBL12448005 | 0.81 | GCK (1.00) | GCKALDH1A1RAB9AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948652-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2011-08-24 | — | — | EP | disclosed |