Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340508 | 0.94 | SYK (0.34) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL2349042 | 0.92 | SYK (0.35) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL1897088 | 0.86 | SYK (0.34) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL2347323 | 0.84 | JAK3 (0.43) | SYKCYP2D6JAK3 | |
| SCHEMBL2341581 | 0.83 | SYK (0.38) | SYKJAK3JAK2JAK1CYP2C9 | |
| SCHEMBL1889949 | 0.82 | SYK (0.35) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL2342919 | 0.82 | JAK3 (0.39) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL1895003 | 0.79 | KDM4E (0.37) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL2345189 | 0.79 | SYK (0.37) | SYKCYP2D6JAK3JAK2JAK1 | |
| SCHEMBL12449311 | 0.77 | SYK (0.38) | SYKCYP2D6JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |