Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ACR | P10323 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338001 | 0.93 | NR1H4 (0.39) | LPAR1LPAR2LPAR3MAPTNPC1 | |
| SCHEMBL2335133 | 0.90 | TP53 (0.34) | CNR2MAPTALDH1A1KDM4ESLC26A6 | |
| SCHEMBL2335317 | 0.85 | LPAR1 (0.38) | LPAR1LPAR2LPAR3NPC1ALDH1A1 | |
| SCHEMBL2332523 | 0.85 | MAPT (0.40) | LPAR1LPAR2LPAR3MAPTNPC1 | |
| SCHEMBL2338262 | 0.83 | LPAR1 (0.50) | LPAR1LPAR2LPAR3NR1H4 | |
| SCHEMBL2339543 | 0.83 | LPAR1 (0.42) | LPAR1LPAR2LPAR3MAPTNPC1 | |
| SCHEMBL3039743 | 0.83 | LPAR1 (0.30) | LPAR1LPAR2LPAR3ACRALDH1A1 | |
| SCHEMBL2338970 | 0.83 | USP2 (0.35) | LPAR1MAPTALDH1A1KDM4ENR1H4 | |
| SCHEMBL2337989 | 0.83 | LPAR1 (0.38) | LPAR1LPAR2LPAR3MAPTACR | |
| SCHEMBL2341943 | 0.82 | CYP4F2 (0.39) | LPAR1LPAR2LPAR3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |