Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.67 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | PPIA | P62937 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334151 | 0.81 | GCK (1.00) | GCKGRM5 | |
| SCHEMBL13439349 | 0.80 | GCK (0.43) | GCKGRM5 | |
| SCHEMBL2339694 | 0.77 | GCK (0.66) | GCKGRM5PPIALTA4HMAPK14 | |
| SCHEMBL2334812 | 0.76 | GCK (0.75) | GCKGRM5PPIA | |
| SCHEMBL23631384 | 0.76 | PPIA (0.66) | GCKGRM5PPIALTA4HMAPK14 | |
| SCHEMBL2342216 | 0.76 | GCK (0.61) | GCKGRM5PPIALTA4HMAPK14 | |
| SCHEMBL1329252 | 0.75 | GCK (0.69) | GCK | |
| Hydrochloric Acid SCHEMBL2340794 | 0.75 | GCK (0.73) | GCKGRM5PPIA | |
| SCHEMBL5582996 | 0.75 | GRM5 (1.00) | GCKGRM5 | |
| SCHEMBL14647654 | 0.74 | GRM5 (0.60) | GCKGRM5PPIALTA4HMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933077-B2 | Glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2015-01-13 | — | — | US | disclosed |
| EP-1948652-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-1948652-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20100056530-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2010-03-04 | — | — | US | disclosed |
| WO-2007053345-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056530-A1 | GLUCOKINASE ACTIVATORS | GCKR, GCK, GALK1 | GCK 2/4885GRM5 1851/4885PPIA 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.