Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 14/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 12/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23236 | 0.90 | HSD17B2 (0.62) | HSD17B2HSD17B1 | |
| SCHEMBL21873 | 0.87 | HSD17B2 (0.62) | HSD17B2HSD17B1 | |
| SCHEMBL21776 | 0.86 | HSD17B2 (0.55) | HSD17B2HSD17B1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12495328 | 0.83 | HSD17B2 (0.60) | HSD17B2HSD17B1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL23125 | 0.81 | HSD17B2 (0.65) | HSD17B2HSD17B1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL24347 | 0.80 | HSD17B2 (0.70) | HSD17B2HSD17B1 | |
| SCHEMBL30843 | 0.79 | HSD17B2 (0.75) | HSD17B2HSD17B1 | |
| SCHEMBL23361 | 0.77 | HDAC6 (0.66) | HSD17B2HSD17B1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL23075 | 0.76 | HDAC6 (0.58) | HSD17B2HSD17B1TUBB4ATUBBTUBA3C | |
| SCHEMBL23339 | 0.76 | HSD17B2 (0.66) | HSD17B2HSD17B1MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |