Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | GCK | P35557 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30600954 | 0.86 | MAP4K1 (0.48) | MAP4K1ABL1GCK | |
| SCHEMBL20517948 | 0.86 | MAP4K1 (0.48) | MAP4K1ABL1GCK | |
| SCHEMBL23429275 | 0.82 | MAP4K1 (0.56) | MAP4K1ABL1 | |
| SCHEMBL20517124 | 0.82 | MAP4K1 (0.78) | MAP4K1ABL1 | |
| SCHEMBL30600787 | 0.82 | MAP4K1 (0.78) | MAP4K1ABL1 | |
| SCHEMBL20519281 | 0.76 | MAP4K1 (0.50) | MAP4K1ABL1GCK | |
| SCHEMBL30107149 | 0.76 | MAP4K1 (0.50) | MAP4K1ABL1GCK | |
| SCHEMBL23429419 | 0.76 | MAP4K1 (0.61) | MAP4K1 | |
| SCHEMBL23429544 | 0.76 | MAP4K1 (0.61) | MAP4K1 | |
| SCHEMBL21859823 | 0.74 | MAP4K1 (0.61) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | HIPK1, HIPK2, IP6K1 | MAP4K1 46/4885ABL1 668/4885GCK 186/4885 |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HIPK1, HIPK2, IP6K1 | MAP4K1 46/4885ABL1 668/4885GCK 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.