Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344414 | 0.94 | SYK (0.57) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2348344 | 0.88 | SYK (0.54) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2338326 | 0.87 | SYK (0.53) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2351567 | 0.86 | SYK (0.62) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2347398 | 0.86 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2274960 | 0.86 | SYK (0.73) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2348385 | 0.85 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2343753 | 0.85 | SYK (0.55) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2343792 | 0.85 | SYK (0.62) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2344666 | 0.85 | SYK (0.60) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |