Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 12/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.47 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21929432 | 0.91 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929580 | 0.90 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929453 | 0.90 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929578 | 0.88 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929439 | 0.88 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929671 | 0.88 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929587 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929676 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929663 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929461 | 0.87 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643717-B1 | 7-SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-06-02 | — | — | EP | disclosed |