Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23442684 | 0.91 | EGFR (0.56) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL23442545 | 0.90 | EGFR (0.59) | EGFRINSRIGF1RALK | |
| SCHEMBL23420406 | 0.90 | EGFR (0.68) | EGFRBTK | |
| SCHEMBL23442608 | 0.89 | EGFR (0.58) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL23441961 | 0.89 | EGFR (0.58) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL23441753 | 0.88 | EGFR (0.59) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL23441732 | 0.88 | EGFR (0.59) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL23442542 | 0.87 | EGFR (0.58) | EGFRAURKAINSRIGF1RROS1 | |
| SCHEMBL22595149 | 0.86 | EGFR (0.66) | EGFR | |
| SCHEMBL23442534 | 0.86 | EGFR (0.78) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021104441-A1 | POLYAROMATIC COMPOUND AS EGFR KINASE INHIBITOR | 江苏先声药业有限公司 | 2021-06-03 | — | — | WO | disclosed |