Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.59 |
| ▸ | IKBKB | O14920 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282391 | 1.00 | CHEK1 (0.59) | CHEK1IKBKBJAK2JAK3KDM4E | |
| SCHEMBL2286306 | 0.89 | CHEK1 (0.57) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1147711 | 0.82 | IKBKB (0.63) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2280534 | 0.81 | CHEK1 (0.57) | CHEK1IKBKBJAK2JAK3KDM4E | |
| SCHEMBL2282752 | 0.80 | CHEK1 (0.55) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2282771 | 0.80 | CHEK1 (0.55) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2344444 | 0.80 | IKBKB (0.64) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2279395 | 0.80 | IKBKB (0.64) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2346009 | 0.80 | CHEK1 (0.56) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1148018 | 0.80 | CHEK1 (0.56) | CHEK1IKBKBJAK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | claimed |