Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.49 |
| ▸ | JAK1 | P23458 | 20/20 | 0.49 |
| ▸ | JAK3 | P52333 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2231030 | 0.87 | JAK2 (0.48) | JAK2JAK1JAK3 | |
| SCHEMBL2231033 | 0.87 | JAK2 (0.48) | JAK2JAK1JAK3 | |
| SCHEMBL2234535 | 0.87 | EGLN2 (0.51) | JAK2JAK1JAK3 | |
| SCHEMBL15167201 | 0.86 | JAK2 (0.48) | JAK2JAK1JAK3 | |
| SCHEMBL2234558 | 0.85 | JAK2 (0.60) | JAK2JAK1JAK3 | |
| SCHEMBL2364610 | 0.83 | JAK2 (0.55) | JAK2JAK1JAK3 | |
| SCHEMBL2232659 | 0.83 | JAK2 (0.55) | JAK2JAK1JAK3 | |
| SCHEMBL2346126 | 0.81 | JAK1 (0.49) | JAK2JAK1JAK3 | |
| SCHEMBL2346123 | 0.81 | JAK1 (0.49) | JAK2JAK1JAK3 | |
| SCHEMBL2231296 | 0.77 | JAK2 (0.41) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536728-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |