SCHEMBL23447014

SCHEMBL23447014

Cc1c(Cl)cccc1NC(=O)Nc1ccc2c(c1O)S(=O)(=O)CCC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 18/20 1.00
TRPV1 Q8NER1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29862683 1.00 CXCR2 (1.00) CXCR2TRPV1
SCHEMBL23446992 0.91 CXCR2 (1.00) CXCR2
SCHEMBL29862657 0.91 CXCR2 (1.00) CXCR2
SCHEMBL28585755 0.90 CXCR2 (1.00) CXCR2
SCHEMBL23446990 0.88 CXCR2 (1.00) CXCR2
SCHEMBL23447016 0.84 CXCR2 (1.00) CXCR2
SCHEMBL29862678 0.84 CXCR2 (1.00) CXCR2
SCHEMBL29862476 0.81 CXCR2 (1.00) CXCR2
SCHEMBL23421496 0.81 CXCR2 (1.00) CXCR2
SCHEMBL23447003 0.81 CXCR2 (1.00) CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112851635-B Cyclic sulfones compound and preparation method, application and pharmaceutical composition thereof 中国医学科学院药物研究所 2022-09-16 CN disclosed
WO-2021104506-A1 CYCLIC SULFONE COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF 中国医学科学院药物研究所 2021-06-03 WO disclosed
CN-112851635-A Cyclic sulfones compound and preparation method, application and pharmaceutical composition thereof 中国医学科学院药物研究所 2021-05-28 CN disclosed