Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272909 | 0.91 | JAK3 (0.60) | JAK3ATRJAK2SYKMAPK1 | |
| SCHEMBL2343741 | 0.84 | JAK3 (0.49) | JAK3MAPK1ROCK2PRKACA | |
| SCHEMBL2279333 | 0.78 | JAK3 (0.61) | JAK3SYKPIK3CAPIK3CGMAPK1 | |
| SCHEMBL2280877 | 0.78 | JAK3 (0.61) | JAK3SYKMAPK1 | |
| SCHEMBL1895617 | 0.77 | JAK3 (0.60) | JAK3SYKPIK3CAMAPK1 | |
| SCHEMBL2280567 | 0.77 | JAK3 (0.60) | JAK3SYKMAPK1 | |
| SCHEMBL2277585 | 0.77 | JAK3 (0.60) | JAK3ATRSYKMAPK1 | |
| SCHEMBL12449934 | 0.77 | JAK3 (0.46) | JAK3MAP4K4BCHEACHESYK | |
| SCHEMBL2271733 | 0.77 | JAK3 (0.60) | JAK3SYKMAPK1 | |
| SCHEMBL2278825 | 0.77 | JAK3 (0.60) | JAK3JAK2SYKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |