Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276326 | 0.85 | SYK (0.61) | SYKCYP2C9JAK3ATRPRKDC | |
| SCHEMBL2344042 | 0.84 | SYK (0.52) | SYKCYP2C9JAK3ATRPRKDC | |
| SCHEMBL2349746 | 0.83 | SYK (0.49) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL2342514 | 0.83 | JAK3 (0.49) | SYKCYP2C9JAK3ATRBTK | |
| SCHEMBL2347616 | 0.83 | SYK (0.46) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL2342554 | 0.80 | ATR (0.46) | SYKCYP2C9JAK3ATRPLK4 | |
| SCHEMBL2339099 | 0.80 | SYK (0.62) | SYKCYP2C9JAK3ATMMAPK1 | |
| SCHEMBL2341691 | 0.77 | SYK (0.43) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2344083 | 0.76 | SYK (0.49) | SYKCYP2C9JAK3ATRMAPK1 | |
| SCHEMBL2346514 | 0.76 | SYK (0.49) | SYKCYP2C9JAK3MAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |