Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | NEK2 | P51955 | 7/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274716 | 0.92 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2280685 | 0.84 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275822 | 0.84 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL13689465 | 0.83 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275089 | 0.83 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277455 | 0.82 | SYK (0.64) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2338325 | 0.82 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279864 | 0.81 | SYK (0.63) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277349 | 0.81 | SYK (0.72) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279485 | 0.81 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |