Sugi Predict

Sugi Predict / Compounds / SCHEMBL23454352

SCHEMBL23454352

SCHEMBL23454352

FC(F)(F)COCc1ccc(-c2cn3c(C(F)(F)Cl)nnc3cn2)cc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 8/20 0.51
▸ SCN5A Q14524 6/20 0.42
▸ ALDH1A1 P00352 2/20 0.35
▸ CHEK1 O14757 2/20 0.35
▸ CHEK2 O96017 2/20 0.35
▸ ABL1 P00519 2/20 0.35
▸ FYN P06241 2/20 0.34
▸ SCN1A P35498 1/20 0.34
▸ SCN2A Q99250 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26329252 0.89 CYP1A2 (0.51) CYP1A2SCN5ACHEK1CHEK2ABL1
SCHEMBL23454372 0.85 CYP1A2 (0.50) CYP1A2SCN5AALDH1A1CHEK1CHEK2
SCHEMBL23454380 0.83 CYP1A2 (0.58) CYP1A2SCN5A
SCHEMBL20204051 0.81 CYP1A2 (0.61) CYP1A2SCN5ASCN1ASCN2A
SCHEMBL23116061 0.81 CYP1A2 (0.58) CYP1A2SCN5AALDH1A1FYN
SCHEMBL20203911 0.79 CYP1A2 (0.64) CYP1A2SCN5AFYNSCN1ASCN2A
SCHEMBL20204050 0.78 CYP1A2 (0.59) CYP1A2SCN5AALDH1A1SCN1ASCN2A
SCHEMBL20191076 0.77 CYP1A2 (0.61) CYP1A2SCN5ACHEK1CHEK2ABL1
SCHEMBL26539337 0.77 CYP1A2 (0.53) CYP1A2SCN5ACHEK1CHEK2ABL1
SCHEMBL26328989 0.77 CYP1A2 (0.50) CYP1A2SCN5ACHEK1CHEK2ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250145629-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2025-05-08 — — US disclosed
US-12145939-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-11-19 — — US disclosed
US-20240043433-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2024-02-08 — — US disclosed
US-11767325-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2023-09-26 — — US disclosed
US-11767325-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2023-09-26 — — US disclosed
US-20210171530-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-06-10 — — US disclosed
US-20210171530-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-06-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12145939-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators SCN1A, SCN2A, SCN5A CYP1A2 1553/4885SCN5A 3/4885ALDH1A1 1576/4885
US-20250145629-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885SCN5A 5/4885ALDH1A1 1953/4885
US-20240043433-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885SCN5A 5/4885ALDH1A1 1953/4885
US-11767325-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators SCN1A, SCN2A, SCN5A CYP1A2 1403/4885SCN5A 3/4885ALDH1A1 1641/4885
US-20210171530-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885SCN5A 5/4885ALDH1A1 1953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.