Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naproxen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.94 |
| ▸ | AKR1C3 | P42330 | 12/20 | 0.94 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | CDC42 | P60953 | 1/20 | 0.94 |
| ▸ | RAC1 | P63000 | 1/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxen SCHEMBL29350675 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL30346195 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3046 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL616149 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29350704 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL28834409 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL10029028 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29360045 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190024-A9 | COMPOSITION COMPRISING BORNYL ACETATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF STRESS-RELATED DISORDER | 경희대학교 산학협력단 | 2021-01-07 | — | — | WO | claimed |
| WO-2020190024-A2 | COMPOSITION COMPRISING BORNYL ACETATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF STRESS-RELATED DISORDER | 경희대학교 산학협력단 | 2020-09-24 | — | — | WO | claimed |
| EP-3834635-B1 | FUNCTIONAL CIGARETTE FILTER CONTAINING NATURAL PLANT MATERIAL, CIGARETTE, AND METHOD FOR PRODUCING SAME | KT & G CORP (KR) | 2024-03-20 | — | — | EP | disclosed |
| US-20230071441-A1 | CIGARETTE FILTER CONTAINING NATURAL PLANT MATERIAL, PREPARATION METHOD THEREOF, AND CIGARETTE INCLUDING THE FILTER | KT & G CORPORATION (KP) | 2023-03-09 | — | — | US | disclosed |
| EP-3834635-A1 | FUNCTIONAL CIGARETTE FILTER CONTAINING NATURAL PLANT MATERIAL, CIGARETTE, AND METHOD FOR PRODUCING SAME | KT & G Corporation (KR) | 2021-06-16 | — | — | EP | disclosed |
| WO-2021080193-A1 | FUNCTIONAL CIGARETTE FILTER CONTAINING NATURAL PLANT MATERIAL, CIGARETTE, AND METHOD FOR PRODUCING SAME | 주식회사 케이티앤지 | 2021-04-29 | — | — | WO | disclosed |
| WO-2020190024-A9 | COMPOSITION COMPRISING BORNYL ACETATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF STRESS-RELATED DISORDER | 경희대학교 산학협력단 | 2021-01-07 | — | — | WO | disclosed |
| WO-2020190024-A2 | COMPOSITION COMPRISING BORNYL ACETATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF STRESS-RELATED DISORDER | 경희대학교 산학협력단 | 2020-09-24 | — | — | WO | disclosed |
| US-20190053545-A1 | METHODS AND SYSTEMS FOR SUBSTANCE REDUCTION VIA ELECTRONIC VAPOR DEVICE DELIVERY | LUNATECH, LLC | 2019-02-21 | — | — | US | disclosed |
| US-8007842-B2 | Composition for inhalation therapy and methods of use | TOWER LABORATORIES, LTD. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20070184000-A1 | COMPOSITION FOR INHALATION THERAPY AND METHODS OF USE | PHYZZ. INC. (US) | 2007-08-09 | — | — | US | disclosed |
| EP-0313302-B1 | PHOTOPROTECTION COMPOSITIONS COMPRISING SORBOHYDROXAMIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 1991-12-18 | — | — | EP | disclosed |
| EP-0313302-A2 | Photoprotection compositions comprising sorbohydroxamic acid | THE PROCTER & GAMBLE COMPANY (US) | 1989-04-26 | — | — | EP | disclosed |