Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | FLT1 | P17948 | 10/20 | 0.51 |
| ▸ | FLT4 | P35916 | 10/20 | 0.51 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10066362 | 0.83 | FLT1 (0.51) | KDRFLT1FLT4ALOX5IMPDH2 | |
| SCHEMBL2339077 | 0.83 | KIT (0.48) | KDRFLT1FLT4SIRT7ALOX5 | |
| SCHEMBL2339289 | 0.82 | FLT1 (0.50) | KDRFLT1FLT4ALOX5IMPDH2 | |
| SCHEMBL2341696 | 0.81 | FLT1 (0.52) | KDRFLT1FLT4ALOX5IMPDH2 | |
| SCHEMBL2349193 | 0.79 | FLT1 (0.46) | KDRFLT1FLT4IMPDH2TRPV1 | |
| SCHEMBL2925824 | 0.79 | KDR (0.55) | KDRFLT1FLT4ALOX5IMPDH2 | |
| SCHEMBL543703 | 0.78 | ABL1 (0.58) | KDRFLT1FLT4SIRT7IMPDH2 | |
| SCHEMBL2341841 | 0.77 | KDR (0.50) | KDRFLT1FLT4IMPDH2 | |
| SCHEMBL2339454 | 0.77 | FLT1 (0.42) | KDRFLT1FLT4ALOX5TRPV1 | |
| SCHEMBL544716 | 0.75 | FLT1 (0.42) | KDRFLT1FLT4ALOX5IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874305-B1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2014-08-27 | — | — | EP | disclosed |
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| CN-101217954-B | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE | 2013-07-10 | — | — | CN | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| US-8080669-B2 | Process for the synthesis of 2-aminoxazole compounds | AB SCIENCE (FR) | 2011-12-20 | — | — | US | disclosed |
| EP-2361624-A1 | Oxazole derivatives and their use as tyrosine kinase inhibitors | AB Science (FR) | 2011-08-31 | — | — | EP | disclosed |
| EP-2361624-A1 | Oxazole derivatives and their use as tyrosine kinase inhibitors | AB Science (FR) | 2011-08-31 | — | — | EP | disclosed |
| EP-2019822-B1 | A NEW PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB SCIENCE (FR) | 2010-09-08 | — | — | EP | disclosed |
| US-20090192317-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB SCIENCE (FR) | 2009-07-30 | — | — | US | disclosed |
| EP-2019822-A1 | A NEW PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB Science (FR) | 2009-02-04 | — | — | EP | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
| CN-101217954-A | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2008-07-09 | — | — | CN | disclosed |
| EP-1874305-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007131953-A1 | A NEW PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB SCIENCE (FR) | 2007-11-22 | — | — | WO | disclosed |
| WO-2006106437-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | KIT, TYRO3, LCK | KDR 240/4885FLT1 168/4885FLT4 110/4885 |
| US-20090192317-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | ABL1, FLT3, ABL2 | KDR 14/4885FLT1 8/4885FLT4 6/4885 |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | KIT, FLT3, LTK | KDR 36/4885FLT1 7/4885FLT4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.