Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345709 | 1.00 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2345734 | 1.00 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2341643 | 0.92 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2341668 | 0.92 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2341927 | 0.90 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2341962 | 0.90 | IKBKB (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2278223 | 0.88 | IKBKB (0.54) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2280765 | 0.88 | IKBKB (0.54) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2280739 | 0.88 | IKBKB (0.54) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2278196 | 0.88 | IKBKB (0.54) | IKBKBJAK2JAK3CHEK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | claimed |
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | disclosed |