Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.45 |
| ▸ | STK17B | O94768 | 4/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2361559 | 0.95 | SYK (0.49) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2343891 | 0.93 | SYK (0.52) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2346422 | 0.90 | PDE4B (0.51) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2279898 | 0.86 | SYK (0.62) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2349695 | 0.86 | MAP4K1 (0.51) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2343170 | 0.84 | KDM5B (0.48) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2349493 | 0.82 | SYK (0.55) | SYKMAP3K11PDE4BCYP2C9NEK2 | |
| SCHEMBL2343816 | 0.82 | SYK (0.47) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2275268 | 0.81 | SYK (0.61) | SYKMAP4K1MAP3K11STK17BSTK17A | |
| SCHEMBL2339060 | 0.81 | SYK (0.53) | SYKMAP4K1MAP3K11PDE4BCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |