Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 19/20 | 0.52 |
| ▸ | VEGFA | P15692 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780232 | 1.00 | EPAS1 (0.52) | EPAS1VEGFA | |
| SCHEMBL23461398 | 0.92 | EPAS1 (0.61) | EPAS1VEGFA | |
| SCHEMBL29780197 | 0.92 | EPAS1 (0.61) | EPAS1VEGFA | |
| SCHEMBL29780186 | 0.90 | EPAS1 (0.63) | EPAS1VEGFA | |
| SCHEMBL23461102 | 0.90 | EPAS1 (0.63) | EPAS1VEGFA | |
| SCHEMBL23461076 | 0.90 | EPAS1 (0.49) | EPAS1VEGFA | |
| SCHEMBL29780219 | 0.90 | EPAS1 (0.49) | EPAS1VEGFA | |
| SCHEMBL23461395 | 0.89 | EPAS1 (0.55) | EPAS1VEGFA | |
| SCHEMBL23461106 | 0.89 | EPAS1 (0.52) | EPAS1VEGFA | |
| SCHEMBL29780237 | 0.89 | EPAS1 (0.52) | EPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024438-A1 | INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4069212-A1 | INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |
| WO-2021113436-A1 | INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021113436-A1 | INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024438-A1 | INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | EPAS1 9/4885VEGFA 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.