Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 6/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275354 | 0.93 | JAK3 (0.40) | CAMK2DPRKCIPOLQJAK2ATR | |
| SCHEMBL2275232 | 0.93 | JAK3 (0.40) | CAMK2DPRKCIPOLQJAK2ATR | |
| SCHEMBL2278185 | 0.92 | JAK3 (0.40) | PRKCIATRF10SYKKIT | |
| SCHEMBL2277366 | 0.86 | PRKCI (0.46) | CAMK2DPRKCIJAK2F10SYK | |
| SCHEMBL2275100 | 0.86 | ATR (0.47) | CAMK2DPOLQJAK2ATRKDM5B | |
| SCHEMBL2274883 | 0.85 | FLT3 (0.43) | PRKCIJAK2SYKCDK1CCNB1 | |
| SCHEMBL2282052 | 0.85 | ATR (0.47) | CAMK2DPOLQJAK2ATRKDM5B | |
| SCHEMBL2275246 | 0.84 | CYP2C9 (0.40) | PRKCIJAK2ATRSYKMAPK1 | |
| SCHEMBL2276821 | 0.84 | PRKCI (0.37) | PRKCIJAK2ATRSYKMAPK1 | |
| SCHEMBL2277416 | 0.82 | MAP4K1 (0.44) | JAK2SYKABL1YES1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |