Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350362 | 0.86 | JAK3 (0.41) | JAK3JAK2JAK1SYK | |
| SCHEMBL1889485 | 0.86 | JAK3 (0.41) | JAK3JAK2JAK1SYK | |
| SCHEMBL2342082 | 0.82 | JAK3 (0.43) | JAK3SYK | |
| SCHEMBL1892114 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1SYK | |
| SCHEMBL2340857 | 0.78 | JAK3 (0.41) | JAK3SYK | |
| SCHEMBL2344168 | 0.78 | JAK3 (0.43) | JAK3JAK2JAK1SYK | |
| SCHEMBL1896043 | 0.74 | JAK3 (0.45) | JAK3SYK | |
| SCHEMBL2340082 | 0.73 | JAK3 (0.43) | JAK3JAK2JAK1 | |
| SCHEMBL2280517 | 0.72 | JAK3 (0.60) | JAK3JAK2JAK1 | |
| SCHEMBL2280999 | 0.71 | JAK3 (0.59) | JAK3JAK2JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |