Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.32 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.32 |
| ▸ | ENGASE | Q8NFI3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20386616 | 0.91 | AGXT (0.39) | AGXTTLR7TLR8LPAR3CRHR1 | |
| SCHEMBL20413272 | 0.88 | AGXT (0.43) | AGXTTLR7TLR8LPAR3CRHR1 | |
| SCHEMBL15469707 | 0.86 | TLR7 (0.46) | AGXTTLR7TLR8 | |
| SCHEMBL20219310 | 0.86 | TLR7 (0.46) | AGXTTLR7TLR8 | |
| SCHEMBL20219533 | 0.81 | AGXT (0.37) | AGXTTLR7TLR8LPAR3CRHR1 | |
| SCHEMBL15469706 | 0.81 | AGXT (0.37) | AGXTTLR7TLR8LPAR3CRHR1 | |
| SCHEMBL20219641 | 0.81 | TLR7 (0.47) | AGXTTLR7TLR8LPAR3CRHR1 | |
| SCHEMBL15470158 | 0.80 | TLR7 (0.43) | AGXTTLR7TLR8LPAR3 | |
| SCHEMBL15470137 | 0.79 | TLR7 (0.54) | AGXTTLR7TLR8 | |
| SCHEMBL20219661 | 0.78 | TLR7 (0.64) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |