Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472457 | 0.90 | TLR7 (0.49) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL15470156 | 0.90 | TLR7 (0.49) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL13195135 | 0.88 | TLR8 (0.50) | TLR8TLR7KCNH2 | |
| SCHEMBL13195743 | 0.87 | TLR8 (0.53) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL13195820 | 0.87 | TLR8 (0.53) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL13195695 | 0.87 | TLR8 (0.53) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL20219323 | 0.87 | TLR8 (0.49) | TLR8TLR7KCNH2 | |
| SCHEMBL15470008 | 0.87 | TLR8 (0.49) | TLR8TLR7KCNH2 | |
| SCHEMBL20413304 | 0.86 | CYP2D6 (0.46) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL20386625 | 0.86 | CYP2D6 (0.46) | TLR8TLR7CYP2D6DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |