Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15469874 | 0.92 | TLR7 (0.56) | TLR7TLR8CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13195840 | 0.91 | TLR7 (0.55) | TLR7TLR8CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13195685 | 0.83 | TLR7 (0.69) | TLR7TLR8CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13195127 | 0.82 | TLR7 (0.55) | TLR7TLR8CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL13195123 | 0.81 | TLR7 (0.54) | TLR7TLR8CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20219387 | 0.80 | CYP1A2 (0.45) | TLR7TLR8CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL13195686 | 0.79 | TLR8 (0.53) | TLR7TLR8CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20219577 | 0.78 | TLR7 (0.49) | TLR7TLR8CYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL13195033 | 0.78 | TLR8 (0.67) | TLR7TLR8CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL15470024 | 0.77 | TLR7 (0.51) | TLR7TLR8CYP1A2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |