Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345444 | 0.91 | SYK (0.62) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2344137 | 0.91 | SYK (0.65) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2339099 | 0.90 | SYK (0.62) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2345306 | 0.86 | SYK (0.58) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2272089 | 0.85 | SYK (1.00) | SYKCYP2C9AAK1MAP4K1JAK2 | |
| SCHEMBL2348404 | 0.82 | SYK (0.55) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2343792 | 0.82 | SYK (0.62) | SYKCYP2C9MAP3K11JAK2JAK1 | |
| SCHEMBL2346603 | 0.81 | SYK (0.59) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2342989 | 0.80 | SYK (0.53) | SYKCYP2C9AAK1MAP4K1MAP3K11 | |
| SCHEMBL2343891 | 0.79 | SYK (0.52) | SYKCYP2C9AAK1MAP4K1MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |