Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348039 | 1.00 | CHEK1 (0.41) | CHEK1MAPK14IKBKBJAK2MEN1 | |
| SCHEMBL2348042 | 1.00 | CHEK1 (0.41) | CHEK1MAPK14IKBKBJAK2MEN1 | |
| SCHEMBL2280684 | 0.92 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2280680 | 0.92 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2280687 | 0.92 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2341718 | 0.91 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2341719 | 0.91 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2341716 | 0.91 | CHEK1 (0.40) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2347663 | 0.91 | CHEK1 (0.38) | CHEK1MAPK14IKBKBJAK2MEN1 | |
| SCHEMBL2347659 | 0.91 | CHEK1 (0.38) | CHEK1MAPK14IKBKBJAK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | disclosed |