SCHEMBL23480413

SCHEMBL23480413

COC(=O)c1cc2ccc(C#Cc3ccc4cc(C(=O)OC)sc4c3)cc2s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.55
MAPT P10636 2/20 0.48
KDM4E B2RXH2 2/20 0.48
HPGD P15428 3/20 0.47
ALDH1A1 P00352 2/20 0.47
HDAC3 O15379 3/20 0.45
HDAC4 P56524 3/20 0.45
HDAC7 Q8WUI4 3/20 0.45
HDAC2 Q92769 3/20 0.45
HDAC10 Q969S8 3/20 0.45
HDAC11 Q96DB2 3/20 0.45
HDAC8 Q9BY41 3/20 0.45
HDAC6 Q9UBN7 3/20 0.45
HDAC9 Q9UKV0 3/20 0.45
HDAC5 Q9UQL6 3/20 0.45
PTPN2 P17706 1/20 0.44
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
DRD2 P14416 1/20 0.40
DRD4 P21917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17149252 0.90 HDAC1 (0.49) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL20097795 0.89 HDAC1 (0.48) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL4948023 0.89 HDAC1 (0.48) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL1495712 0.88 HDAC1 (0.52) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL4947829 0.88 HDAC1 (0.52) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL2250510 0.81 HDAC1 (0.69) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL31207822 0.81 HDAC1 (0.57) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL1886145 0.81 HDAC1 (0.80) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL3747465 0.81 HDAC1 (0.57) HDAC1MAPTKDM4EHPGDALDH1A1
SCHEMBL31207866 0.81 HDAC1 (0.69) HDAC1MAPTKDM4EHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021113679-A1 DIMERIC COMPOUNDS AS STING AGONISTS MERSANA THERAPEUTICS, INC. (US) 2021-06-10 WO disclosed