Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 11/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 8/20 | 0.62 |
| ▸ | FLT1 | P17948 | 6/20 | 0.62 |
| ▸ | FLT4 | P35916 | 6/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355542 | 0.88 | FGFR1 (0.61) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL2355675 | 0.84 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL2351653 | 0.83 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL2349401 | 0.83 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL465419 | 0.83 | FGFR1 (0.64) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL12863165 | 0.81 | FGFR1 (0.60) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL2350863 | 0.80 | FGFR1 (0.65) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL16367921 | 0.78 | FGFR4 (0.75) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL31648262 | 0.77 | FGFR1 (0.76) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL1248489 | 0.77 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163522-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | US | claimed |
| US-7504406-B2 | Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same | SANOFI-AVENTIS (FR) | 2009-03-17 | — | — | US | claimed |
| US-20080176874-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | US | claimed |
| EP-1902054-A1 | DERIVATIVES OF PYRIDO[2,3-D]PYRIMIDINE, THE PREPARATION THEREOF AND THE THERAPEUTIC APPLICATION OF THE SAME | Sanofi-Aventis (FR) | 2008-03-26 | — | — | EP | claimed |
| WO-2007003765-A1 | DERIVATIVES OF PYRIDO[2,3-D]PYRIMIDINE, THE PREPARATION THEREOF, AND THE THERAPEUTIC APPLICATION OF THE SAME | SANOFI AVENTIS (FR) | 2007-01-11 | — | — | WO | claimed |
| US-8008310-B2 | Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same | SANOFI-AVENTIS (FR) | 2011-08-30 | — | — | US | disclosed |
| US-20090163522-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | US | disclosed |
| US-7504406-B2 | Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same | SANOFI-AVENTIS (FR) | 2009-03-17 | — | — | US | disclosed |
| EP-1902054-B1 | DERIVATIVES OF PYRIDO[2,3-D]PYRIMIDINE, THE PREPARATION THEREOF AND THE THERAPEUTIC APPLICATION OF THE SAME | SANOFI AVENTIS (FR) | 2009-02-18 | — | — | EP | disclosed |
| EP-2020410-A1 | Pyrido[2,3d]pyrimidine derivatives, process for their preparation and their therapeutical use | sanofi-aventis (FR) | 2009-02-04 | — | — | EP | disclosed |
| US-20080176874-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | US | disclosed |
| EP-1902054-A1 | DERIVATIVES OF PYRIDO[2,3-D]PYRIMIDINE, THE PREPARATION THEREOF AND THE THERAPEUTIC APPLICATION OF THE SAME | Sanofi-Aventis (FR) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007003765-A1 | DERIVATIVES OF PYRIDO[2,3-D]PYRIMIDINE, THE PREPARATION THEREOF, AND THE THERAPEUTIC APPLICATION OF THE SAME | SANOFI AVENTIS (FR) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176874-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | DPYD, TYMP, TYMS | FGFR1 2373/4885FGFR4 1163/4885FGFR2 1763/4885 |
| US-20090163522-A1 | Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same | DPYD, TYMP, TYMS | FGFR1 2373/4885FGFR4 1163/4885FGFR2 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.