Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.46 |
| ▸ | SYK | P43405 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276394 | 0.96 | JAK3 (0.49) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2280584 | 0.90 | JAK3 (0.46) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2275915 | 0.89 | JAK3 (0.45) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2276253 | 0.89 | JAK3 (0.45) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL2278026 | 0.88 | JAK3 (0.44) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2278229 | 0.88 | SYK (0.47) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2278709 | 0.87 | JAK3 (0.55) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL2273689 | 0.87 | JAK3 (0.44) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL2276249 | 0.87 | JAK3 (0.49) | JAK3SYKKCNH2CYP2C9JAK2 | |
| SCHEMBL2281125 | 0.86 | JAK3 (0.54) | JAK3SYKKCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |