Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047534 | 0.93 | TLR8 (0.34) | TLR8TLR7MCHR1KDM4EMEN1 | |
| SCHEMBL23502460 | 0.91 | TLR8 (0.35) | TLR8TLR7MCHR1KDM4EMEN1 | |
| SCHEMBL23502475 | 0.89 | TLR8 (0.33) | TLR8TLR7KDM4ETP53MAPT | |
| SCHEMBL20047453 | 0.84 | KDM4E (0.32) | TLR8TLR7KDM4EMEN1ALDH1A1 | |
| SCHEMBL20047567 | 0.73 | CNR2 (0.35) | TLR8TLR7KDM4ETP53MAPT | |
| SCHEMBL23502538 | 0.72 | TLR8 (0.39) | TLR8MCHR1GPBAR1 | |
| SCHEMBL23502449 | 0.72 | NR1H2 (0.33) | KDM4EMAPT | |
| SCHEMBL23502473 | 0.71 | TLR8 (0.33) | TLR8TLR7 | |
| SCHEMBL23502478 | 0.69 | MCHR1 (0.38) | TLR8MCHR1KDM4EMAPTGPBAR1 | |
| SCHEMBL20047581 | 0.69 | TLR8 (0.32) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034684-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2021-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034684-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | GPBAR1, SLC10A1, NR1H4 | TLR8 901/4885TLR7 491/4885MCHR1 1496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.