Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.42 |
| ▸ | CCND1 | P24385 | 7/20 | 0.42 |
| ▸ | CCND2 | P30279 | 5/20 | 0.42 |
| ▸ | CCND3 | P30281 | 5/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419390 | 0.78 | CDK4 (0.35) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL17807777 | 0.78 | CDK4 (0.44) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL20251396 | 0.76 | CSNK1E (0.39) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL22419361 | 0.72 | CASR (0.44) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL17807809 | 0.71 | CDK4 (0.37) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL19199989 | 0.71 | KDM4E (0.36) | — | |
| SCHEMBL19200146 | 0.70 | POLB (0.44) | CDK1 | |
| SCHEMBL25463635 | 0.67 | CDK4 (0.58) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL25004173 | 0.67 | CDK4 (0.67) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL23507951 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210177855-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD. (CA) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210177855-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD2 | CDK4 238/4885CCND1 1185/4885CCND2 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.