SCHEMBL2350847

SCHEMBL2350847

Cc1nc(C(=O)C(N)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 13/20 0.63
THRA P10827 4/20 0.63
THRB P10828 4/20 0.63
BBOX1 O75936 1/20 0.63
SLC6A2 P23975 1/20 0.63
SLC6A3 Q01959 1/20 0.63
ASPH Q12797 1/20 0.63
KDM8 Q8N371 1/20 0.63
FTO Q9C0B1 1/20 0.63
EGLN2 Q96KS0 12/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4551499 0.91 EGLN1 (0.53) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL30401668 0.91 EGLN1 (0.55) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL4551839 0.86 EGLN1 (0.53) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL16280563 0.85 EGLN1 (0.68) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL14672078 0.85 EGLN1 (0.71) EGLN1THRATHRBBBOX1SLC6A2
Acetic Acid SCHEMBL30394209 0.83 EGLN1 (0.65) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL14941692 0.83 EGLN1 (0.50) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL31267308 0.82 EGLN1 (0.70) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL29046746 0.82 EGLN1 (0.67) EGLN1THRATHRBBBOX1SLC6A2
SCHEMBL14672080 0.82 EGLN1 (0.70) EGLN1THRATHRBBBOX1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3003284-A1 PHARMACEUTICAL FORMULATIONS OF A HIF HYDROXYLASE INHIBITOR Fibrogen, Inc. (US) 2016-04-13 EP claimed
WO-2014197660-A1 PHARMACEUTICAL FORMULATIONS OF A HIF HYDROXYLASE INHIBITOR FIBROGEN, INC. (US) 2014-12-11 WO claimed
WO-2025029611-A1 THERAPIES FOR DISEASES OF COPPER METABOLISM THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2025-02-06 WO disclosed
CN-117999069-A Pediatric formulation of ferric citrate 凯克斯生物制药公司 2024-05-07 CN disclosed
EP-4347022-A1 PEDIATRIC FORMULATIONS OF FERRIC CITRATE Keryx Biopharmaceuticals, Inc. (US) 2024-04-10 EP disclosed
EP-4138825-A1 TREATMENT OF VIRAL INFECTIONS, OF ORGAN INJURY, AND OF RELATED CONDITIONS USING A HIF PROLYL HYDROXYLASE INHIBITOR OR A HIF-ALPHA STABILIZER Akebia Therapeutics Inc. (US) 2023-03-01 EP disclosed
WO-2022251563-A1 PEDIATRIC FORMULATIONS OF FERRIC CITRATE KERYX BIOPHARMACEUTICALS, INC. (US) 2022-12-01 WO disclosed
WO-2022150623-A1 COMPOUNDS AND COMPOSITION FOR THE TREATMENT OF ANEMIA AKEBIA THERAPEUTICS, INC. (US) 2022-07-14 WO disclosed
WO-2021216530-A1 TREATMENT OF VIRAL INFECTIONS, OF ORGAN INJURY, AND OF RELATED CONDITIONS USING A HIF PROLYL HYDROXYLASE INHIBITOR OR A HIF-ALPHA STABILIZER AKEBIA THERAPEUTICS, INC. (US) 2021-10-28 WO disclosed
EP-3003284-A1 PHARMACEUTICAL FORMULATIONS OF A HIF HYDROXYLASE INHIBITOR Fibrogen, Inc. (US) 2016-04-13 EP disclosed
WO-2014197660-A1 PHARMACEUTICAL FORMULATIONS OF A HIF HYDROXYLASE INHIBITOR FIBROGEN, INC. (US) 2014-12-11 WO disclosed
WO-2013070908-A1 THERAPEUTIC METHOD FIBROGEN, INC. (US) 2013-05-16 WO disclosed
EP-2357175-A1 isoquinoline derivatives AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN Fibrogen, Inc. (US) 2011-08-17 EP disclosed