Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26041630 | 1.00 | KRAS (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512988 | 1.00 | KRAS (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512867 | 0.92 | USP30 (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512533 | 0.92 | USP30 (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL26041581 | 0.89 | KRAS (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL29693105 | 0.89 | KRAS (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512813 | 0.89 | KRAS (0.40) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512564 | 0.88 | KRAS (0.45) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23512814 | 0.88 | KRAS (0.45) | KRASHDAC6USP30TP53SMARCA2 | |
| SCHEMBL23496716 | 0.85 | KRAS (0.41) | KRASDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339968-A1 | KRAS Gl2C INHIBITORS | ELI LILLY AND COMPANY | 2023-10-26 | — | — | US | disclosed |
| US-20230339968-A1 | KRAS Gl2C INHIBITORS | ELI LILLY AND COMPANY | 2023-10-26 | — | — | US | disclosed |
| WO-2023196887-A1 | METHOD OF TREATMENT INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023196959-A1 | PROCESS FOR MAKING A KRAS G12C INHIBITOR | ELI LILLY AND COMPANY (US) | 2023-10-12 | — | — | WO | disclosed |
| US-11731984-B2 | KRas G12C inhibitors | ELI LILLY AND COMPANY (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731984-B2 | KRas G12C inhibitors | ELI LILLY AND COMPANY (US) | 2023-08-22 | — | — | US | disclosed |
| US-20210179633-A1 | KRAS G12C INHIBITORS | ELI LILLY AND COMPANY | 2021-06-17 | — | — | US | disclosed |
| WO-2021118877-A1 | KRAS G12C INHIBITORS | ELI LILLY AND COMPANY (US) | 2021-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339968-A1 | KRAS Gl2C INHIBITORS | KRAS, NRAS, GLS2 | KRAS 1/4885HDAC6 1340/4885USP30 3416/4885 |
| US-11731984-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | KRAS 1/4885HDAC6 1738/4885USP30 2637/4885 |
| US-20210179633-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | KRAS 1/4885HDAC6 1738/4885USP30 2637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.