Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22170676 | 0.85 | GBA1 (0.51) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL20343398 | 0.84 | SCN1A (0.56) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL21946389 | 0.83 | GBA1 (0.50) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL20936966 | 0.80 | CHRM5 (0.56) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL23519981 | 0.80 | CHRM5 (0.56) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL20936956 | 0.80 | CHRM5 (0.56) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL21947701 | 0.80 | GBA1 (0.47) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL24319179 | 0.80 | GBA1 (0.47) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL24379284 | 0.77 | GBA1 (0.61) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL21192977 | 0.77 | GBA1 (0.51) | GBA1SCN1ASCN4ASCN7AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021119254-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2021-06-17 | — | — | WO | disclosed |