SCHEMBL2353153

SCHEMBL2353153

O=C(NC(COCc1ccccc1)C(=O)Nc1ccc(Oc2ccccc2)cc1)c1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 11/20 0.72
PGR P06401 1/20 0.54
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TAOK1 Q7L7X3 1/20 0.49
TAOK3 Q9H2K8 1/20 0.49
HDAC1 Q13547 2/20 0.49
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
EPHX1 P07099 1/20 0.48
MEN1 O00255 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3126793 0.95 S1PR1 (0.68) S1PR1PGRNPC1RAB9ASMN1; SMN2
SCHEMBL13393047 0.95 S1PR1 (0.68) S1PR1PGRNPC1RAB9ASMN1; SMN2
SCHEMBL1372535 0.93 S1PR1 (0.66) S1PR1PGRSMN1; SMN2HDAC1
SCHEMBL1374223 0.93 S1PR1 (0.66) S1PR1PGRNPC1RAB9ATAOK1
SCHEMBL1372313 0.93 S1PR1 (0.66) S1PR1PGRNPC1RAB9ASMN1; SMN2
SCHEMBL1375973 0.92 S1PR1 (0.64) S1PR1PGRNPC1RAB9ATAOK1
SCHEMBL12044728 0.91 S1PR1 (0.63) S1PR1PGRNPC1RAB9ASMN1; SMN2
SCHEMBL1374302 0.91 S1PR1 (0.63) S1PR1NPC1RAB9ASMN1; SMN2TAOK1
SCHEMBL1372290 0.91 S1PR1 (0.63) S1PR1PGRNPC1RAB9ASMN1; SMN2
SCHEMBL1373370 0.90 S1PR1 (0.62) S1PR1PGRRAB9ATAOK1TAOK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349252-A2 SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS Exelixis, Inc. (US) 2011-08-03 EP disclosed
WO-2010045601-A2 SYNERGISTIC EFFECTS BETWEEN SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS EXELIXIS, INC. (US) 2010-04-22 WO disclosed