SCHEMBL23534293

SCHEMBL23534293

CC1(C)NCCc2ccc(NC(=O)c3n[nH]c4ccc(-c5cccnc5F)cc34)cc21

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 19/20 0.59
CLK2 P49760 3/20 0.59
CLK3 P49761 3/20 0.59
WNT1 P04628 11/20 0.49
GSK3B P49841 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31123859 1.00 DYRK1A (0.59) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL23533947 0.85 DYRK1A (0.59) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL29754087 0.85 DYRK1A (0.59) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL29754038 0.84 DYRK1A (0.62) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL23533925 0.84 DYRK1A (0.62) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL28809179 0.84 DYRK1A (0.59) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL29754049 0.84 DYRK1A (0.59) DYRK1ACLK2CLK3WNT1GSK3B
Hydrochloric Acid SCHEMBL23533915 0.84 DYRK1A (0.61) DYRK1ACLK2CLK3WNT1GSK3B
Hydrochloric Acid SCHEMBL29753926 0.84 DYRK1A (0.61) DYRK1ACLK2CLK3WNT1GSK3B
SCHEMBL23533909 0.83 DYRK1A (0.58) DYRK1ACLK2CLK3WNT1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114867718-A Novel indazole derivative and use thereof 韩国化学研究院 2022-08-05 CN claimed
CN-114867718-A Novel indazole derivative and use thereof 韩国化学研究院 2022-08-05 CN disclosed
WO-2021125802-A1 NOVEL INDAZOLE DERIVATIVE, AND USE THEREOF 한국화학연구원 2021-06-24 WO disclosed