Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535598 | 1.00 | SLC18A3 (0.64) | SLC18A3GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL23535597 | 1.00 | SLC18A3 (0.64) | SLC18A3GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL2794231 | 0.90 | FUCA1 (0.55) | SLC18A3GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL13229558 | 0.90 | FUCA1 (0.55) | SLC18A3GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL23553675 | 0.87 | SLC18A3 (0.56) | SLC18A3GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL23553483 | 0.85 | SLC18A3 (0.56) | SLC18A3GRIN1GRIN2BSIGMAR1FUCA1 | |
| SCHEMBL2187946 | 0.82 | SLC18A3 (0.76) | SLC18A3SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL2187939 | 0.82 | SLC18A3 (0.76) | SLC18A3SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL2187943 | 0.82 | SLC18A3 (0.76) | SLC18A3SIGMAR1FUCA1ALDH1A1 | |
| SCHEMBL2191616 | 0.81 | SLC18A3 (0.74) | SLC18A3SIGMAR1FUCA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087638-B | PRMT5 inhibitors | 默沙东公司 | 2023-11-24 | — | — | CN | disclosed |
| EP-4077282-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087638-A | PRMT5 inhibitor | 默沙东公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021126731-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021126731-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |