Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13424862 | 0.76 | CDK7 (0.34) | PSMD14CDK7CDK9KDM4EMEN1 | |
| SCHEMBL9697101 | 0.76 | KDM4E (0.61) | PIM2CDK9KDM4EMEN1ALDH1A1 | |
| SCHEMBL3227382 | 0.76 | FLT3 (0.36) | PIM1PSMD14CDK7CDK9KDM4E | |
| SCHEMBL3209524 | 0.75 | FLT3 (0.40) | PIM1PSMD14CDK7CDK9KDM4E | |
| SCHEMBL23536767 | 0.74 | KDR (0.34) | CDK7CDK9KDM4EMEN1ALDH1A1 | |
| SCHEMBL3627711 | 0.73 | SLC6A4 (0.64) | KDM4EHSD17B10 | |
| SCHEMBL2630746 | 0.72 | PDE10A (0.41) | PDE10APIK3CDPIK3CAPDCD1CD274 | |
| SCHEMBL2250102 | 0.72 | BACE1 (0.42) | PDE10APIK3CDPIK3CAPDCD1CD274 | |
| SCHEMBL2457269 | 0.72 | BACE1 (0.49) | PDE10APIK3CDPIK3CAPDCD1CD274 | |
| SCHEMBL25244381 | 0.70 | HTR2A (0.56) | PSMD14CDK7CDK9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |