Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 11/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10351893 | 0.88 | TAAR1 (0.48) | TAAR1HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL15787168 | 0.86 | TAAR1 (0.47) | TAAR1HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL6405866 | 0.85 | TAAR1 (0.46) | TAAR1HTR2AMPOKIF11 | |
| SCHEMBL13064220 | 0.81 | TAAR1 (0.39) | TAAR1MPO | |
| SCHEMBL31061956 | 0.80 | TAAR1 (0.67) | TAAR1HTR2AMPOSLC6A4HRH1 | |
| SCHEMBL2210035 | 0.80 | TAAR1 (0.67) | TAAR1HTR2AMPOSLC6A4HRH1 | |
| SCHEMBL21323656 | 0.79 | TAAR1 (0.38) | TAAR1MPOKIF11 | |
| SCHEMBL8441509 | 0.79 | TAAR1 (0.38) | TAAR1MPOKIF11 | |
| SCHEMBL10830835 | 0.79 | TAAR1 (0.38) | TAAR1HTR2AMPOKIF11 | |
| SCHEMBL16958402 | 0.79 | TAAR1 (0.38) | TAAR1MAPTMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |